Basics of NMR

Nuclear Magnetic Resonance spectroscopy (NMR)

NMR is an analysis technique relying on the magnetic resonance phenomenon of nuclei that have a number of spin I different than zero. The most conventional nuclei used in NMR are: 1H; 13C ; 19F; 31P. This technique requires an intense B0 magnetic field.

For specific applications, the NMR of other nuclei has also developed, for example the NMR of the 2H; 29Si; 14N; 11B and 10B, 23Na, 17O….and many more.

Some experiments on samples in a solution:

  • Structural characterization of small organic molecules and proteins
  • Study of mixtures (ex: composition, dosage)
  • Determination of equilibrium constants (slow and fast exchange, chemical exchange and conformational exchange, etc.)
  • Kinetic studies (rate constant, reaction monitoring, etc.)

Some experiments on solid samples:

  • Characterization of inorganic solid materials
  • Characterization of gel type polymers (follow-up of reactions in solid phase)

Application areas:

Pharmaceutical, food, medical (MRI), quality control, etc.
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